Associate Professor, Health and Kinesiology
Office#: 127 Human Clinical Research Facility
Mail Stop: 1542
Office Phone: (979) 220-2282
Other Title: Co-director CTRAL
Primary Emphasis Area: Kinesiology
Vita: View Document
Short Bio
Experience : Dr. Marielle Engelen, PhD, Associate Professor, currently serves as CoDirector and Head of Clinical Research for the Center for Translational Research in Aging and Longevity (CTRAL). She is an expert in the field of nutrition and metabolism in chronic diseases. Her research focuses on the metabolic alterations underlying involuntary weight loss and muscle wasting in chronic inflammatory diseases, involving the use of stable isotope methodologies, and the effects of dietary modulation and exercise intervention to restore metabolism and physical performance in these patients. As such, she has conducted and supervised many acute studies and coordinating human clinical trials, examining the effects of protein and amino acid intervention in healthy elderly and in those with chronic wasting diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, cognitive impairment). In addition, she has the expertise in methodology and techniques to examine body composition, muscle function, physical performance, gut and cognitive function, and wellbeing. Education: Dr. Engelen studied Health Sciences (Movement Sciences) at Maastricht University, Maastricht, the Netherlands. In 1994, she worked as Research Associate at the Dept. of Respiratory and Critical Care Medicine at Harbor UCLA Medical Center, Torrance, CA (director: Karlman Wasserman, MD, PhD). After she returned to the Netherlands, she worked as a PhD student at the Dept. of Respiratory Medicine at the Academic Hospital Maastricht and obtained her PhD in 2000 (title thesis: "Muscle wasting in COPD: a metabolic and functional perspective"), and subsequently worked as a postdoctoral fellow at the Dept of Surgery. Learn more about Dr. Engelen by visiting her page on CTRAL's website
Research Interests
chronic diseases and aging
stable isotopes
Publications (journal articles, books, book chapters)*

1. Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016. doi: 10.3945/ajcn.115.125187. PubMed PMID: 27146652

2. Engelen MP, van der Meij BS, Deutz NE. Protein anabolic resistance in cancer: does it really exist? Curr Opin Clin Nutr Metab Care. 2016;19(1):39-47. doi: 10.1097/MCO.0000000000000236. PubMed PMID: 26560520

3. Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. Reduced arginine availability and nitric oxide synthesis in cancer is related to impaired endogenous arginine synthesis. Clinical Science. 2016. Doi: 10.1042/cs20160233

4. Ligthart-Melis GC, Marini JC, Engelen MP, Deutz NE. Glutamine supplementation, citrulline production, and de novo arginine synthesis: is there a relation? The American Journal of Clinical Nutrition. 2015;101(4):890-2. doi: 10.3945/ajcn.114.104679.

5. Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2015;26(9):1960-6. doi: 10.1093/annonc/mdv271. PubMed PMID: 26113648; PMCID: PMC4551158

6. Tsien C, Davuluri G, Singh D, Allawy A, Ten Have GA, Thapaliya S, Schulze JM, Barnes D, McCullough AJ, Engelen MP, Deutz NE, Dasarathy S. Metabolic and molecular responses to leucine enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology (Baltimore, Md. 2015. doi: 10.1002/hep.27717. PubMed PMID: 25613922.

7. Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion. Clin Nutr. 2014;33(2):211-20. doi: 10.1016/j.clnu.2013.06.014. PubMed PMID: 23886411; PubMed Central PMCID: PMC3883994.

8. Engelen MP, Com G, Deutz NE. Increased whole body hydroxyproline production as assessed by a new stable isotope technique is associated with hip and spine bone mineral loss in cystic fibrosis. Clin Nutr. 2014;33(6):1117-21. doi: 10.1016/j.clnu.2013.12.008. PubMed PMID: 24423745.

9. Engelen M.P.K.J. Com G., Anderson P.J., Deutz N.E.P. New Stable Isotope Method to Measure Protein Digestibility and Response to Pancreatic Enzyme Intake in Cystic Fibrosis, Clin. Nutr. 2014, 33: 1024-32

10. Engelen MPKJ, Com G, Deutz NEP. Protein is an important but undervalued macronutrient in the nutritional care of patients with cystic fibrosis. Current Opinion in Clinical Nutrition & Metabolic Care. 2014;17 (6), 515-520. Publish Ahead of Print:10.1097/MCO.0000000000000100.

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* Publication was joint-authored with students
Diss Publication was from a dissertation
ROS Publication was from a record of study

College of Education and Human Development Grants and Contracts (Current)

Effects of Low Fose of Fish Oil (EPA+DHA) vs. combined EPA+DHA and HMB or Curcumin Supplementation on Protein Metabolism, Muscle Mass and Functional Capacity in Moderate to Severe COPD. (Co-PI)
Abbott Nutrition (Private)
2017/11/07 - 2018/11/07
Total Funding: 337,496.

Role of Metabolic Phenotyping, Changes in Gut Function and the Response to a Meal to Explain the Variability in Weight Loss induced by Very Low Caloric Diet in (Morbidly) Obese Adults. (PI)
European Society for Clinical Nutrition and Metabolism (Private)
2017/09/01 - 2019/08/31
Total Funding: 57,880.

PESCA: Intramuscular Metabolic Phenotyping to Identify Muscle Dysfunction in Older Adults with Chronic Disease. (PI)
TAMU Office of the Vice President for Research (State)
2017/05/01 - 2018/04/30
Total Funding: 25,000.

Catapult Round 3 - Linking Metabolic Phenotype to Mood and Neurocognitive Functions in Autism Spectrum Disorder (Funded amount $30,000). (Co-PI)
TAMU College of Education & Human Development (State)
2016/12/01 - 2018/05/31
Total Funding: 0.
Courses Taught
HLKN Faculty   |   HLKN Staff