Office#: Human Clinical Research Facility
Mail Stop: 4253
Office Phone: (979) 220-2910
Primary Emphasis Area: Kinesiology
Vita: View Document
Short Bio
Experience : Dr. Nicolaas Deutz, MD, PhD currently serves as Director for the Center for Translational Research in Aging and Longevity (CTRAL). For more than 30 years, his research background and expertise focus on nutrition, metabolism, and physiology studies involving the use of stable isotope methodologies, both in humans and animals. Dr. Deutz has extensive experience with isotopic calculations, validation and data interpretation. The stable isotope approaches are used in several studies to unravel the metabolic changes in patients with chronic diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, mild cognitive impairment and dementia, autism spectrum disorder). This research leads to new insights in protein and amino acid kinetics in subjects with chronic disease and resulted in specific recommendations to nutritional supplements as method for reducing muscle wasting. Recently, he started studying the anabolic effects of specialized nutritional supplements in different chronic diseases and models of disease. Using translational approaches is a logical extension of the body of his research in the field of protein and amino acids metabolism. Education: Dr. Deutz obtained his MD and PhD at the University of Amsterdam, Netherlands. He is a medical physiologist and Nutrition Physician Specialist. Learn more about Dr. Deutz by visiting his page on CTRAL's website
Research Interests
amino acids
chroninc disease
clinical nutrition
older adults
Publications (journal articles, books, book chapters)*

1. Hakvoort, T., He, Y., Kulik, W., Vermeulen, J. L., Duijst, S., Ruijter, J. M., Runge, JH, Deutz, N.E.P., Koehler, S.E., Lamers, W. H. (2017). Pivotal role of glutamine synthetase in ammonia detoxification. Hepatology, 65(1), 281-293

2. Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016. doi: 10.3945/ajcn.115.125187. PubMed PMID: 27146652

3. Heyland DK, Stapleton RD, Mourtzakis M, Hough CL, Morris P, Deutz NE, Colantuoni E, Day A, Prado CM, Needham DM. Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues. Clin Nutr. 2016;35(5):1196-206. doi: 10.1016/j.clnu.2015.07.003. PubMed PMID: 26212171

4. Deutz NE, Matheson EM, Matarese LE, Baggs GE, Nelson JL, Hegazi RA, Luo M, Tappenden KA, Ziegler TR, Group NS. Reply, Letter to the Editor - Supplemental and energy likely account for multi-ingredient supplementation in mitigating morbidity and mortality in compromised elderly malnourished patients. Clin Nutr. 2016. doi: 10.1016/j.clnu.2016.03.027. PubMed PMID: 27091771

5. Engelen MP, van der Meij BS, Deutz NE. Protein anabolic resistance in cancer: does it really exist? Curr Opin Clin Nutr Metab Care. 2016;19(1):39-47. doi: 10.1097/MCO.0000000000000236. PubMed PMID: 26560520; PMCID: PMC4731087.

6. Engelen MP, van der Meij BS, Deutz NE. Protein anabolic resistance in cancer: does it really exist? Curr Opin Clin Nutr Metab Care. 2016;19(1):39-47. doi: 10.1097/MCO.0000000000000236. PubMed PMID: 26560520

7. Oshima T, Deutz NE, Doig G, Wischmeyer PE, Pichard C. Protein-energy nutrition in the ICU is the power couple: A hypothesis forming analysis. Clin Nutr. 2016;35(4):968-74. doi: 10.1016/j.clnu.2015.10.016. PubMed PMID: 26608526

8. Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. Reduced arginine availability and nitric oxide synthesis in cancer is related to impaired endogenous arginine synthesis. Clinical Science. 2016. Doi: 10.1042/cs20160233

9. Kim IY, Schutzler SE, Schrader A, Spencer HJ, Azhar G, Deutz NE, Wolfe RR. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure. American journal of physiology. 2015;309(11):E915-24. doi: 10.1152/ajpendo.00339.2015

10. Walker DK, Thaden JJ, Deutz NEP. Application of gas chromatography[48]13tandem mass spectrometry (GC/MS/MS) for the analysis of deuterium enrichment of water. Journal of Mass Spectrometry. 2015;50(6):838-43. doi: 10.1002/jms.3593.

Show All

* Publication was joint-authored with students
Diss Publication was from a dissertation
ROS Publication was from a record of study

College of Education and Human Development Grants and Contracts (Current)

Catapult Round 4 Center - CTRAL Clinical Research Symposium ($5,000). (PI)
TAMU College of Education & Human Development (State)
2018/01/15 - 2019/06/15
Total Funding: 0.

Effects of Low Fose of Fish Oil (EPA+DHA) vs. combined EPA+DHA and HMB or Curcumin Supplementation on Protein Metabolism, Muscle Mass and Functional Capacity in Moderate to Severe COPD. (PI)
Abbott Nutrition (Private)
2017/11/07 - 2018/11/07
Total Funding: 337,496.

Preclinical Study in Pig Sepsis Model to Evaluate the Efficacy of HMB on Whole Body Protein Turnover using Pulse Labeling Methodology. (PI)
Abbott Nutrition (Private)
2017/09/29 - 2018/09/29
Total Funding: 76,000.

Strategic Transformative Research Program: Assessment of Metabolism with Exhaled Breath Biomarkers. (Co-PI)
TAMU College of Science (State)
2017/09/01 - 2018/08/31
Total Funding: 25,000.

Role of Metabolic Phenotyping, Changes in Gut Function and the Response to a Meal to Explain the Variability in Weight Loss induced by Very Low Caloric Diet in (Morbidly) Obese Adults. (Co-PI)
European Society for Clinical Nutrition and Metabolism (Private)
2017/09/01 - 2019/08/31
Total Funding: 57,880.

Engineering Research Center for Precise Advanced Technologies andHealth Systems for Underserved Populations (PATHS-UP). (Co-PI)
National Science Foundation (Federal)
2017/08/01 - 2022/07/31
Total Funding: 30,225.

BL 20 - Testing of blood samples for HMB and amino acids. (PI)
Abbott Nutrition (Private)
2017/04/24 - 2018/04/23
Total Funding: 60,800.

A Randomized Double Blinded Controlled Trial of an Oral Nutritional Supplement Containing AN 777 in Older Hospitalized Patients. (PI)
Abbott Nutrition (Private)
2017/04/04 - 2018/04/04
Total Funding: 73,600.

Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trail of Combined Cycle Ergometry and Amino Acids in the ICU. (PI)
University of Vermont - NIH (Federal)
2017/04/01 - 2022/03/31
Total Funding: 112,697.

Catapult Round 3 - Linking Metabolic Phenotype to Mood and Neurocognitive Functions in Autism Spectrum Disorder (Funded amount $30,000). (Co-PI)
TAMU College of Education & Human Development (State)
2016/12/01 - 2018/05/31
Total Funding: 0.

Integrated Health Sciences Core. (PI)
Texas A&M Agrilife Research-National Institutes of Health (Federal)
2014/04/01 - 2019/03/31
Total Funding: 92,140.
Courses Taught
2012 - 2013
KINE 685
Editorial Positions

Editor (2016 - ). The journal of nutrition health and aging

editor (2013 - ). Clinical Nutrition

Editor (2013 - ). e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism;


(2013-2013). ESPEN Followship.  Effect of enteral nutritional intervention on glutathione metabolism during Pseudomonas aeruginosa induced sepsis in the pig

HLKN Faculty   |   HLKN Staff